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海外小核酸行业动态跟踪:ASO疗法先驱者(附下载)

  • 2026-02-18 11:15:48
海外小核酸行业动态跟踪:ASO疗法先驱者(附下载)

内容摘要

TRYNGOLZA（olezarsen）有望拓展适应症，切入SHTG市场。TRYNGOLZA目前获批适应症为用于成人FCS患者饮食辅助来降低甘油三酯水平，FCS在美国的发病率约为百万分之一到百万分之十三，市场容量有限。SHTG患病人群较为广泛，美国预计超300万人患有SHTG。现有的治疗药物包括贝特类和ω-3类药物，但疗效较为有限，存在较大未被满足的临床治疗需求。Ionis在2025年11月披露了olezarsen治疗SHTG的关键性III期CORE和CORE2研究结果，两项研究均达到了主要终点，针对sHTG适应症预计2026年提交上市申请。

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海外小核酸行业动态跟踪之Ionis：ASO疗法先驱者，后续有望迎来多个里程碑事件催化-260114-平安证券-16页

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  137. /yingpanguazai/ssd/ssd1/www/mffb.com.cn/vendor/topthink/think-template/src/template/driver/File.php ( 2.41 KB )
  138. /yingpanguazai/ssd/ssd1/www/mffb.com.cn/vendor/topthink/think-template/src/template/contract/DriverInterface.php ( 0.86 KB )
  139. /yingpanguazai/ssd/ssd1/www/mffb.com.cn/runtime/temp/49e0cd3e0528281c5c5fae705243dc37.php ( 11.98 KB )
  140. /yingpanguazai/ssd/ssd1/www/mffb.com.cn/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.000919s ] mysql:host=127.0.0.1;port=3306;dbname=no_mfffb;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001490s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000704s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000668s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001297s ]
  6. SELECT * FROM `set` [ RunTime:0.000588s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001372s ]
  8. SELECT * FROM `article` WHERE `id` = 465998 LIMIT 1 [ RunTime:0.000964s ]
  9. UPDATE `article` SET `lasttime` = 1771780062 WHERE `id` = 465998 [ RunTime:0.003853s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000579s ]
  11. SELECT * FROM `article` WHERE `id` < 465998 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.001009s ]
  12. SELECT * FROM `article` WHERE `id` > 465998 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.001023s ]
  13. SELECT * FROM `article` WHERE `id` < 465998 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.008012s ]
  14. SELECT * FROM `article` WHERE `id` < 465998 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.004536s ]
  15. SELECT * FROM `article` WHERE `id` < 465998 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.002305s ]
0.118090s